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The connection between Serotonin effects and clinical depression has long been a familiar aspect to medicine and research subjects. The inter relation though was of debate – whether it was depression which caused serotonin levels to decrease in the body or the other way around. The development in this faculty has lead to the belief that it is, in fact, low levels of serotonin that leads to depression. Natural Antidepressant and what to do before using folic acid is given as a substitute to boost the level of Serotonin.
Understanding Serotonin
Serotonin, a natural antidepressant in our nervous system, lies in a cluster of neurons. It is mainly responsible for all the psychological aspects of human activity and behavior. Its implications include sleep, mood, sexual attitude, etc. On a general overview, it produces an inhibitory effect on the nervous system thereby giving the feeling of calm, soothe and satiety. Natural Antidepressant, like l-huperzine a in any case should not be consumed for a long period of time as it may cause various side effects.
In the case of depression, it is not possible to implicate low levels of serotonin as the only cause, but yes, it is very much a fact that serotonin effects acts as one of the main catalysts in the path of depression.
Depression Information
Statistically speaking, approximately 5% of the United States’ population suffers from depression, with at least one episode requiring treatment per year. This condition is found twice as common in females than in males. An alteration in the metabolism and levels of serotonin has been found to play an important role. Variation in the level of serotonin, especially, in regions such as the hypothalamus, amygdala, and other areas of the cortex which are responsible for the higher neuronal activity, have a great impact on the mood.
This hypothesis can also be proven by the efficacy of Selective Serotonin Reuptake inhibitors. The presynaptic cell terminates the Serotonin effect by causing its reuptake. SSRIs block this reuptake of serotonin, leading to increased serotonergic action since the amount of serotonin remaining in the synapse is almost nil.
Serotonin Information
Another consistent finding in depressed patients with the help of Seratonin Information is the increased activity of HPA i.e.Hypothalamic Pituitary Adrenal system. This increase is proven by the failure of the Dexamethasone test. This can also be due to increased Vasopressin secretion and of Corticotropin releasing hormone.
Down-regulation of glucocorticoid receptors (GR) or mineralocorticoid receptors (MR) in the hippocampus can be derailed which is also another important factor.
The levels of Serotonin is low in persons who are regular users of Serotonin MDMA (methylene-di-oxy-meth-amphetamine), also called as Serotonin Ecstasy.
The indoleamine hypothesis, can be also proven by the fact that the levels of 5-hydroxyindolacetic (5-HIAA) acid, a serotonin metabolite,also can be a Natural antidepressant are low. These are found in the cerebral spinal fluid of patients suffering from depression.This reduction of 5-HIAA is clearer and more conspicuous in depressed patients especially those who have a history of attempted suicide.
On the usage of 5HTP, studies have shown that the beta-endorphins are significantly increased in chronically depressed patients, as well as in usage of Serotonin MDMA that colloquially is called Serotonin Ecstasy.
On stimulation of the serotonin system, hormones, prolactin and growth hormone are released. Their responses were decreased in depressed patients. This shows that levels of serotonin are disturbed in cases of depression. Hence, proving its action as a Natural Antidepressant.
Serotonin Information also helps in motor activity. The serotonic system of the brain controls motor activity of the body and sense processing, both of which are inter-related. This can be the explanation of the inability of depressed patients to carry out simple monotonous tasks even of day-to-day life. The same applies to chronic users of Serotonin Ecstasy or Serotonin MDMA.
It should be noted that the treatment modalities have been proved successful in at least 80-90% of patients. The treatment is anti depressant drugs that are available in the market or supplements of 5-HTP or tryptophan. Studies have also shown that treatment with 5HTP is superior to placebo therapy. These were proven using the Serotonin Effects antagonistic to action of Serotonin Ecstasy. Serotonin MDMA is always to be used after your doctor prescribes the dosage. Understanding of the Seratonin Information and the effects with the help of your physician can be a wise decision to stay away from major ailments.
