What Is The History Of Tricyclic Antidepressants

A synthetic or natural antidepressant is a psychiatric medication that is used to treat or alleviate the symptoms of mood disorders such as depression, anxiety, and bipolar disorder. Depression is one of the most commonly reported and diagnosed serotonin production in the developed world and it is typically characterized by an all-encompassing low mood accompanied by low self esteem, and by a loss of interest and pleasure in normally enjoyable activities.

Tricyclic Antidepressant Information

This syndrome has affected people for thousands of years and has long been recognized as a medical ailment. For this reason, a plethora of herbal and other natural antidepressants have been used in order to treat the illness and improve a person’s mood throughout history.

However, according to available tricyclic antidepressant information, the tricyclic class of drugs, the first of its kind, was discovered in December of 1950 by Paul Charpentier, a scientist from Rhone-Poulenc. Charpentier discovered the drug while trying to synthesize chlorpromazine by manipulating synthetic antihistamines that were first developed by Rhone-Poulenc in the 1940s.

Further Uses Of Tricyclic Antidepressants

By the mid 1950s, the drug was being commonly used in hospitals throughout Paris, although it was not originally used to what does 5 htp mean to treat depression. However, in 1955 the substance’s tricyclic antidepressant effects were first noticed and by 1957 multiple clinical trials had been run in order to uncover more tricyclic antidepressant information.

Tricyclic Antidepressant Successful In Treating Depression

At this time, doctors and scientists discovered that tricyclic antidepressants affect the balance of naturally occurring chemicals found within the brain known as noradrenaline and serotonin. These chemicals play a very important part in the neurological system because they allow neurons in the brain to communicate with each other and to control or regulate bodily functions, including mood, pain, and sleeping patterns. It was discovered that, much like some natural antidepressants, tricyclic antidepressants were capable of providing a noradrenaline and serotonin boost in the brain.

This discovery was significant because it is now known that a person who is depressed may have a low amount of these two chemicals active in their brain. By preventing the reabsorption of these neurotransmitters, the drug is able to enhance a person’s mood and treat depression. Since this discovery, the ability to provide a noradrenaline and serotonin boost in the brain has been the most prized tricyclic antidepressant effect.

Within a few years, tricyclic antidepressants were being used to give a noradrenaline and serotonin boost to huge numbers of patients diagnosed with depression, largely replacing many earlier natural antidepressants according to available tricyclic antidepressant information. It wasn’t long after the psychiatric tricyclic antidepressant effects were discovered that the drug began generating significant revenue around the world.

In fact, tricyclic antidepressants became the standard treatment for depression for many years. However, after newer drugs were discovered that provided the same noradrenaline and serotonin boost without many of the negative side effects associated with tricyclic antidepressants, the drug fell out of use in most parts of the world.